A comparison between left ventricular ejection time measurement methods during physiological changes induced by simulated microgravity

Stefan Orter, Stefan Orter, Stefan Möstl, Martin Bachler, Fabian Hoffmann, Christopher Clemens Mayer, Eugenijus Kaniusas, Michaela Reisinger, Siegfried Wassertheurer, Jens Tank, Jens Jordan, Bernhard Hametner, Bernhard Hametner

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung


Systolic time intervals that are easy to detect might be used as parameters reflecting cardiovascular deconditioning. We compared left ventricular ejection time (LVET) measured via ultrasound Doppler on the left ventricular outflow tract with oscillometrically measured LVET, measured at the brachialis. Furthermore, we assessed the progression of the left ventricular ejection time index (LVETI), the pre-ejection period index (PEPI), the Weissler index (PEP/LVET) and the total electromechanical systole index (QS2I) during prolonged strict head-down tilt (HDT) bed rest, including 16 male and eight female subjects. Simultaneous oscillometric and echocardiographic LVET measurements showed significant correlation (r = 0.53 with P = 0.0084 before bed rest and r = 0.73 with P < 0.05 on the last day of bed rest). The shortening of LVET during HDT bed rest measured with both approaches was highly concordant in their effect direction, with a concordance rate of 0.96. Our results also demonstrated a significant decrease of LVETI (P < 0.0001) and QS2I (P = 0.0992) and a prolongation of PEPI (P = 0.0049) and PEP/LVET (P = 0.0003) during HDT bed rest over 60 days. Four days after bed rest, LVETI recovered completely to its baseline value. Owing to the relationship between shortening of LVETI and heart failure progression, the easy-to-use oscillometric method might not only be a useful way to evaluate the cardiovascular system during space flights, but could also be of high value in a clinical setting.
Seiten (von - bis)213-221
FachzeitschriftExperimental Physiology
PublikationsstatusVeröffentlicht - 2022

Research Field

  • Ehemaliges Research Field - Capturing Experience
  • Medical Signal Analysis


  • head-down tilt bed rest
  • left ventricular ejection time
  • oscillometry
  • systolic time intervals
  • validation


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