A genome-wide search for linkage to asthma. German Asthma Genetics Group

M Wjst; G Fischer; T Immervoll; M Jung; K Saar; F Rueschendorf; A Reis; M Ulbrecht; M Gomolka; E H Weiss; L Jaeger; R Nickel; K Richter; N I Kjellman; M Griese; A von Berg; M Gappa; F Riedel; M Boehle; S van Koningsbruggen; P Schoberth; R Szczepanski; W Dorsch; M Silbermann; H E Wichmann

doi:10.1006/geno.1999.5806

A genome-wide search for linkage to asthma. German Asthma Genetics Group

M Wjst, G Fischer, T Immervoll, M Jung, K Saar, F Rueschendorf, A Reis, M Ulbrecht, M Gomolka, E H Weiss, L Jaeger, R Nickel, K Richter, N I Kjellman, M Griese, A von Berg, M Gappa, F Riedel, M Boehle, S van KoningsbruggenP Schoberth, R Szczepanski, W Dorsch, M Silbermann, H E Wichmann

Molecular Diagnostics

GSF-Forschungszentrum fuer Umwelt und Gesundheit

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

Abstract

Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for atopy in British/Australian families and for asthma in different American populations showed inconsistent results. We report a sib pair study of a sample of 97 families, including 415 persons and 156 sib pairs. Following an extensive clinical evaluation, all participants were genotyped for 351 polymorphic dinucleotide markers. Linkage analysis for asthma identified four chromosomal regions that could to be linked to asthma: chromosome 2 (at marker D2S2298, P = 0.007), chromosome 6 (around D6S291, lowest P = 0.008), chromosome 9 (proximal to D9S1784, P = 0.007), and chromosome 12 (D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific immunoglobulin E (minimum P values at these regions were 0. 003, 0.001, 0.010, and 0.015, respectively).

Originalsprache	Englisch
Seiten (von - bis)	1-8
Seitenumfang	8
Fachzeitschrift	Genomics
Volume	58
Issue	1
DOIs	https://doi.org/10.1006/geno.1999.5806
Publikationsstatus	Veröffentlicht - 15 Mai 1999

Research Field

Molecular Diagnostics

UN SDGs

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10.1006/geno.1999.5806

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Wjst, M., Fischer, G., Immervoll, T., Jung, M., Saar, K., Rueschendorf, F., Reis, A., Ulbrecht, M., Gomolka, M., Weiss, E. H., Jaeger, L., Nickel, R., Richter, K., Kjellman, N. I., Griese, M., von Berg, A., Gappa, M., Riedel, F., Boehle, M., ... Wichmann, H. E. (1999). A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics, 58(1), 1-8. https://doi.org/10.1006/geno.1999.5806

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title = "A genome-wide search for linkage to asthma. German Asthma Genetics Group",

abstract = "Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for atopy in British/Australian families and for asthma in different American populations showed inconsistent results. We report a sib pair study of a sample of 97 families, including 415 persons and 156 sib pairs. Following an extensive clinical evaluation, all participants were genotyped for 351 polymorphic dinucleotide markers. Linkage analysis for asthma identified four chromosomal regions that could to be linked to asthma: chromosome 2 (at marker D2S2298, P = 0.007), chromosome 6 (around D6S291, lowest P = 0.008), chromosome 9 (proximal to D9S1784, P = 0.007), and chromosome 12 (D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific immunoglobulin E (minimum P values at these regions were 0. 003, 0.001, 0.010, and 0.015, respectively).",

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Wjst, M, Fischer, G, Immervoll, T, Jung, M, Saar, K, Rueschendorf, F, Reis, A, Ulbrecht, M, Gomolka, M, Weiss, EH, Jaeger, L, Nickel, R, Richter, K, Kjellman, NI, Griese, M, von Berg, A, Gappa, M, Riedel, F, Boehle, M, van Koningsbruggen, S, Schoberth, P, Szczepanski, R, Dorsch, W, Silbermann, M & Wichmann, HE 1999, 'A genome-wide search for linkage to asthma. German Asthma Genetics Group', Genomics, Vol. 58, Nr. 1, S. 1-8. https://doi.org/10.1006/geno.1999.5806

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AU - Wjst, M

AU - Fischer, G

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AU - Jung, M

AU - Saar, K

AU - Rueschendorf, F

AU - Reis, A

AU - Ulbrecht, M

AU - Gomolka, M

AU - Weiss, E H

AU - Jaeger, L

AU - Nickel, R

AU - Richter, K

AU - Kjellman, N I

AU - Griese, M

AU - von Berg, A

AU - Gappa, M

AU - Riedel, F

AU - Boehle, M

AU - van Koningsbruggen, S

AU - Schoberth, P

AU - Szczepanski, R

AU - Dorsch, W

AU - Silbermann, M

AU - Wichmann, H E

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N2 - Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for atopy in British/Australian families and for asthma in different American populations showed inconsistent results. We report a sib pair study of a sample of 97 families, including 415 persons and 156 sib pairs. Following an extensive clinical evaluation, all participants were genotyped for 351 polymorphic dinucleotide markers. Linkage analysis for asthma identified four chromosomal regions that could to be linked to asthma: chromosome 2 (at marker D2S2298, P = 0.007), chromosome 6 (around D6S291, lowest P = 0.008), chromosome 9 (proximal to D9S1784, P = 0.007), and chromosome 12 (D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific immunoglobulin E (minimum P values at these regions were 0. 003, 0.001, 0.010, and 0.015, respectively).

AB - Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for atopy in British/Australian families and for asthma in different American populations showed inconsistent results. We report a sib pair study of a sample of 97 families, including 415 persons and 156 sib pairs. Following an extensive clinical evaluation, all participants were genotyped for 351 polymorphic dinucleotide markers. Linkage analysis for asthma identified four chromosomal regions that could to be linked to asthma: chromosome 2 (at marker D2S2298, P = 0.007), chromosome 6 (around D6S291, lowest P = 0.008), chromosome 9 (proximal to D9S1784, P = 0.007), and chromosome 12 (D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific immunoglobulin E (minimum P values at these regions were 0. 003, 0.001, 0.010, and 0.015, respectively).

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KW - Chromosomes, Human, Pair 2/genetics

KW - Chromosomes, Human, Pair 6/genetics

KW - Chromosomes, Human, Pair 9/genetics

KW - Family Health

KW - Female

KW - Genetic Linkage

KW - Genetic Markers

KW - Genome, Human

KW - Germany

KW - Humans

KW - Immunoglobulin E/blood

KW - Male

KW - Phenotype

KW - Radioallergosorbent Test

U2 - 10.1006/geno.1999.5806

DO - 10.1006/geno.1999.5806

M3 - Article

C2 - 10333435

SN - 0888-7543

VL - 58

SP - 1

EP - 8

JO - Genomics

JF - Genomics

IS - 1

ER -

A genome-wide search for linkage to asthma. German Asthma Genetics Group

Abstract

Research Field

UN SDGs

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