“Clickable” graphene nanoribbons for biosensor interfaces

Roger Hasler, Gonzalo Eduardo Fenoy, Alicia Götz, Veronica Montes-Garcia, Cataldo Valentini, Zijie Qiu, Christoph Kleber, Paolo Samori, Klaus Müllen, Wolfgang Knoll

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung


We report on the synthesis of “clickable” graphene nanoribbons (GNRs) and their application as a versatile interface for electrochemical biosensors. GNRs are successfully deposited on gold-coated working electrodes and serve as a platform for the covalent anchoring of a bioreceptor (i.e., a DNA aptamer), enabling selective and sensitive detection of Interleukin 6 (IL6). Moreover, when applied as the intermediate linker on reduced graphene oxide (rGO)-based field-effect transistors (FETs), the GNRs provide improved robustness compared to conventional aromatic bi-functional linker molecules. GNRs enable an orthogonal and covalent attachment of a recognition unit with a considerably higher probe density than previously established methods. Interestingly, we demonstrate that GNRs introduce photoluminescence (PL) when applied to rGO-based FETs, paving the way toward the simultaneous optical and electronic probing of the attached biointerface.
FachzeitschriftNanoscale Horizons
PublikationsstatusVeröffentlicht - 22 Feb. 2024

Research Field

  • Biosensor Technologies


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