Collective localized surface plasmon-enhanced fluorescence for high performance biosensors

Martin Bauch, Jakub Dostalek

    Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

    Abstract

    Metallic nanostructures supporting collective localized surface plasmons (cLSPs) are investigated for the amplification of signal in fluorescence biosensors. cLSPs modes are supported by diffractive Arrays of metallic nanoparticles that are embedded in a refractive indexsymmetrical environment. They exhibit lower damping and thus their excitation is associated with higher field intensity enhancement and narrower resonance than that for regular localized surface plasmons. Through finite difference time domain (FDTD) simulations, we designed a novel cLSP structure that exhibit two resonances overlapping with absorption and emission wavelengths of assumed fluorophore (similar to Cy5 or Alexa Fluor 647). The simulations of surface plasmon-enhanced fluorescence (PEF) took into account the cLSP-driven excitation, directional emission, and mediated quantum yield in realistic Sandwich immunoassays that utilize fluorophore-labeled detection antibodies. Achieved results indicate that cLSP-based structures holds potential for extraordinarily high fluorescence intensity enhancement that exceeds a value of 103.
    OriginalspracheEnglisch
    Seiten (von - bis)20470-20483
    Seitenumfang14
    FachzeitschriftOptics Express
    Volume21
    Issue17
    DOIs
    PublikationsstatusVeröffentlicht - 2013

    Research Field

    • Biosensor Technologies

    Schlagwörter

    • Surface Plasmons;Spectroscopy
    • fluorescence and luminescence;Biological sensing and sensors;Subwavelength

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