TY - JOUR
T1 - Field-Effect Transistor with a Plasmonic Fiber Optic Gate Electrode as a Multivariable Biosensor Device
AU - Hasler, Roger
AU - Reiner-Rozman, Ciril
AU - Fossati, Stefan
AU - Aspermair, Patrik
AU - Dostalek, Jakub
AU - Lee, Seungho
AU - Ibanez, Maria
AU - Bintinger, Johannes
AU - Knoll, Wolfgang
PY - 2022
Y1 - 2022
N2 - A novel multivariable system, combining a transistor with fiber optic-based surface plasmon resonance spectroscopy with the gate electrode simultaneously acting as the fiber optic sensor surface, is reported. The dual-mode sensor allows for discrimination of mass and charge contributions for binding assays on the same sensor surface. Furthermore, we optimize the sensor geometry by investigating the influence of the fiber area to transistor channel area ratio and distance. We show that larger fiber optic tip diameters are favorable for electronic and optical signals and demonstrate the reversibility of plasmon resonance wavelength shifts after electric field application. As a proof of principle, a layer-by-layer assembly of polyelectrolytes is performed to benchmark the system against multivariable sensing platforms with planar surface plasmon resonance configurations. Furthermore, the biosensing performance is assessed using a thrombin binding assay with surface-immobilized aptamers as receptors, allowing for the detection of medically relevant thrombin concentrations.
AB - A novel multivariable system, combining a transistor with fiber optic-based surface plasmon resonance spectroscopy with the gate electrode simultaneously acting as the fiber optic sensor surface, is reported. The dual-mode sensor allows for discrimination of mass and charge contributions for binding assays on the same sensor surface. Furthermore, we optimize the sensor geometry by investigating the influence of the fiber area to transistor channel area ratio and distance. We show that larger fiber optic tip diameters are favorable for electronic and optical signals and demonstrate the reversibility of plasmon resonance wavelength shifts after electric field application. As a proof of principle, a layer-by-layer assembly of polyelectrolytes is performed to benchmark the system against multivariable sensing platforms with planar surface plasmon resonance configurations. Furthermore, the biosensing performance is assessed using a thrombin binding assay with surface-immobilized aptamers as receptors, allowing for the detection of medically relevant thrombin concentrations.
KW - electrolyte-gated field-effect transistor (EG-FET) surface plasmon resonance (SPR) layer-by-layer (LBL) assemblies surface investigation
KW - electrolyte-gated field-effect transistor (EG-FET) surface plasmon resonance (SPR) layer-by-layer (LBL) assemblies surface investigation
U2 - 10.1021/acssensors.1c02313
DO - 10.1021/acssensors.1c02313
M3 - Article
SN - 2379-3694
VL - 7
SP - 504
EP - 512
JO - ACS Sensors
JF - ACS Sensors
IS - 2
ER -