Hydrogel-Terminated Photonic Crystal for Label-Free Detection of Angiopoietin-1

Francesca Frascella, Christian Petri, Serena Ricciardi, Lucia Napione, Peter Munzert, Ulrich Jonas, Jakub Dostalek, Federico Bussolino, Candido Pirri, Emiliano Descrovi

    Publikation: Beitrag in FachzeitschriftArtikelBegutachtung


    We report on a label-free, time-resolved biosensing technique based on refractometric measurements. A onedimensional photonic crystal (1DPC) constituted by a planar stack of dielectric layers is used for supporting Bloch Surface Waves (BSWs). These electromagnetic surface waves probe the aqueous environment within few hundreds of nanometers from the photonic crystal surface, which is functionalized with a hydrogel binding matrix. Therein, selected antibodies are grafted for the specific recognition of the tumoral biomarker Angiopoietin-1. A model bioassay is established demonstrating a detection of Antiopoiegin-1 as low as picomolar concentrations.
    FachzeitschriftJournal of Lightwave Technology
    PublikationsstatusVeröffentlicht - 2016

    Research Field

    • Biosensor Technologies


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