Abstract
Poly(ADP-ribose) is a polyanion involved in the regulation of the DNA metabolism of cells. DNA repair, semiconservative DNA- synthesis, differentiation- and transformation functions are connected to changes in the activity of the poly(ADP-ribose)- polymerase. The incidence of most cancers shows a steady increase with age while the PAR-synthesis decreases linear in certain cells with age. In some diseases abnormalities could be detected in PAR-synthesis and binding to nuclear proteins. (Author)
Originalsprache | Deutsch |
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Seiten (von - bis) | 861-864 |
Seitenumfang | 4 |
Fachzeitschrift | Wien. Klin. Wochenschr.(Dec 1983) |
Publikationsstatus | Veröffentlicht - 1983 |
Research Field
- Nicht definiert
Schlagwörter
- FZS-000BLP