Quantification and Stability of Salbutamol in Human Urine

Guro Forsdahl, Thomas Geisendorfer, Guenter Gmeiner

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung


A sensitive method for the quantification of free salbutamol in human urine is described. Sample clean up is performed using SPE an a mixed phase extraction column. Derivatisation is performed with N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA) and the extract is analysed by GC-MS. The method was found to be suitable for use in the doping field, where a cut-off limit of 1 ILg salbutamol/mL urine is set by the International Olympic Committee (IOC) and approved by the World Anti-Doping Agency (WADA). Above that value a doping violation occurs. In addition, the stability of salbutamol in human urine has been evaluated.
Seiten (von - bis)110-114
FachzeitschriftJournal of Separation Science
PublikationsstatusVeröffentlicht - 2004

Research Field

  • Biosensor Technologies


  • salbutamol
  • gas chromatography
  • mass spectrometry
  • solid phase extraction
  • urine
  • doping


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