Real‐Time Monitoring of Nanoparticle Cytotoxicity By Contactless Dielectric Sensing

In the last decade the usage of nanoparticles (NP) in industrial and medical applications has enormously increased. As humans are exposed to engineered NP there is an urgent need for rapid and reliable screening procedures to identify the hazardous potential of nanomaterials. A label‐free, non‐invasive measurement system based on contactless electric cell‐substrate impedance spectroscopy (cECIS) has been developed and applied to study cellular activity in the absence and presence of low NP doses. In the presented work we demonstrate the ability of the in‐house built measurement system to detect toxic impacts of silver NP concentrations on primary human cells under cell culture conditions.