Abstract
Cellular Automaton theory has proved to be an
innovative and reliable tool in describing complex
processes such as tumor growth. This was shown
in previous studies and will be extended here with
the intention of simulating the tumor's response to
radiation therapy. Computation of such models
compared with clinical data from oncology could
provide a deeper understanding of tumor
dynamics. The model presented in this paper bases
on an inhomogeneous oxygen environment.
Therefore an arterial tree serves as input for the
oxygen distribution that is calculated by a diffusion
process. The oxygen distribution on the other hand
serves as input for the cellular automaton which
governs the growth of the simulated tumor.
Angiogenesis is introduced by subsequent
modification of the vascular network. The
parameters are fine-tuned in order to attain the
pattern of Gompertzian growth, which is very well
documented in clinical studies. The model
presented here can be used to simulate tumor
growth and it's response to radiation therapy.
Comparison with clinical data can lead to a more
detailed understanding of tumor dynamics and
their response to radiation therapy.
Originalsprache | Englisch |
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Titel | Proceedings |
Seitenumfang | 2 |
Publikationsstatus | Veröffentlicht - 2006 |
Veranstaltung | Proceedings, Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Biomedizinische Technik - Dauer: 1 Jan. 2006 → … |
Konferenz
Konferenz | Proceedings, Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Biomedizinische Technik |
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Zeitraum | 1/01/06 → … |
Research Field
- Nicht definiert
Schlagwörter
- Simulation
- tumor growth Angiogenesis