Research output per year
Research output per year
Research output
- 1 - 50 out of 106 results
Search results
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2024
Effects of small extracellular vesicles derived from normoxia- and hypoxia-treated prostate cancer cells on the submandibular salivary gland epithelium in vitro
Špilak, A., Brachner, A., Friedl, H.-P., Klepe, A., Nöhammer, C. & Neuhaus, W., 9 May 2024, In: Tissue Barriers. p. 2347062Research output: Contribution to journal › Article › peer-review
Open Access -
Establishment of an in vitro patient-derived hiPSC-based blood-brain barrier model of Syngap1 disorder
Kardos-Török, N. (Speaker), Gerhartl, A., Brachner, A., Rojas, C., Rumbaugh, G., Holleman, T., Jung, M. & Neuhaus, W., 25 Jun 2024.Research output: Poster presentation without proceedings › peer-review
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Generation and Characterization of a Human Neuronal In Vitro Model for Rett Syndrome Using a Direct Reprogramming Method
Huber, A., Sarne, V., Beribisky, A. V., Ackerbauer, D., Derdak, S., Madritsch, S., Etzler, J., Huck, S., Scholze, P., Gorgulu, I., Christodoulou, J., Studenik, C. R., Neuhaus, W., Connor, B., Laccone, F. & Steinkellner, H., 4 Mar 2024, In: Stem Cells and Development. 33, 5-6, p. 128-142 15 p.Research output: Contribution to journal › Article › peer-review
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Investigation of protein replacement therapy for Rett syndrome using directly reprogrammed neurons
Steinkellner, H. (Speaker), Huber, A. M., Sarne, V., Beribisky, A. V., Derdak, S., Madritsch, S., Christodoulou, J., Huck, S., Connor, B., Neuhaus, W. & Laccone, F., 25 Jun 2024.Research output: Poster presentation without proceedings › peer-review
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In vitro ischemia alters barrier integrity and influences particle release in the presence of small extracellular vesicles at the blood-brain barrier
Klepe, A. (Speaker), Spilak, A., Brachner, A., Nöhammer, C. & Neuhaus, W., 28 May 2024.Research output: Poster presentation without proceedings
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In vitro strategies to improve cellular maturity of hiPSC-derived blood-brain barrier endothelium
Mathew – Schmitt, S. (Speaker), Glaser, M., Gaetzner, S., Schmitt, L., Brachner, A., Jahnke, H. G., Piontek, J., Neuhaus, W., Oertner, S. & Appelt-Menzel, A. (Speaker), 10 Jul 2024.Research output: Poster presentation without proceedings › peer-review
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KIF5B – the culprit in an unclassified skeletal dysplasia ?
Sarne, V., Huber, A., Beribisky, A., Steinkellner, H., Arnhold, R., Nikkels, P., Neuhaus, W., Dechat, T. & Laccone, F., 20 May 2024, Abstracts of the ECTS 2024 Congress, 25-28 May 2024, Marseille, France. EISSN 2473-4039 ed. P270, Vol. 8. p. i1–i340Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Poster Presentation › peer-review
Open Access -
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P. J., Escher, B. I., Dirven, H., Hellsten, K., Dolva, K., Hessel, E., Heusinkveld, H. J., Hadzhiev, Y., Hurem, S., Jagiello, K., Judzinska, B., Klüver, N. & Knoll-Gellida, A. & 14 others, , 26 Apr 2024, In: Frontiers in Toxicology. 6, p. 1359507Research output: Contribution to journal › Article › peer-review
Open Access -
Small extracellular vesicle-brain endothelial cell interactome identified by proximity-dependent biotinylation at the blood-brain barrier in vitro.
Klepe, A. (Speaker), Spilak, A., Brachner, A., Nöhammer, C. & Neuhaus, W., 25 Jun 2024.Research output: Poster presentation without proceedings › peer-review
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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Bell, R. D., Letoha, T., Meyer, A. H. & Leparc, G. & 7 others, , 21 Mar 2024, In: European Journal of Cell Biology. 103, 2, p. 151406Research output: Contribution to journal › Article › peer-review
Open Access -
Towards closing the gap of blood-brain barrier data for neurotoxicity assessment: Establishment of human blood-brain barrier in vitro models for adult and developmental neurotoxicity testing (Task 5.2.1e)
Panke, K. (Speaker), Pitzl, C., Brachner, A. & Neuhaus, W., 27 May 2024.Research output: Poster presentation without proceedings
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Transport of Non-Steroidal Anti-Inflammatory Drugs across an Oral Mucosa Epithelium In Vitro Model
Lin, G., Friedl, H.-P., Grabner, S., Gerhartl, A. & Neuhaus, W., 15 Apr 2024, In: Pharmaceutics. 543.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A hydrogel model of the human blood-brain barrier using differentiated stem cells
Singh, N. R., Gromnicova, R., Brachner, A., Kraev, I., Romero, I. A., Neuhaus, W. & Male, D., 4 Apr 2023, In: PLoS ONE. 18, 4, p. e0283954 19 p., e0283954.Research output: Contribution to journal › Article › peer-review
Open Access -
A primary cell-based in vitro model of the human small intestine reveals host olfactomedin 4 induction in response to Salmonella Typhimurium infection
Däullary, T., Imdahl, F., Dietrich, O., Hepp, L., Krammer, T., Fey, C., Neuhaus, W., Metzger, M., Vogel, J., Westermann, A. J., Saliba, A.-E. & Zdzieblo, D., 20 Mar 2023, In: Gut Microbes. 15, 1, 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Ozgür, B., Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, M., Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Brodin, B., 19 Dec 2023, In: Fluids and Barriers of the CNS. 20, 15 p., 96.Research output: Contribution to journal › Article › peer-review
Open Access -
Differential effects of small extracellular vesicles derived from normoxia and hypoxia treated prostate cancer cells on a salivary gland epithelium model in vitro
Spilak, A., Brachner, A., Nöhammer, C. & Neuhaus, W., 9 Nov 2023, p. 245.Research output: Poster presentation without proceedings
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Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases
Khalil, A., Barras, A., Boukherroub, R., Tseng, C.-L., Devos, D., Burnouf, T., Neuhaus, W. & Szunerits, S., 13 Sept 2023, In: Nanoscale Horizons. 9, 1, p. 14-43 30 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease
Haferkamp, U., Hartmann, C., Abid, C. L., Brachner, A., Höchner, A., Gerhartl, A., Harwardt, B., Leckzik, S., Leu, J., Metzger, M., Nastainczyk-Wulf, M., Neuhaus, W., Oerter, S., Pless, O., Rujescu, D., Jung, M. & Appelt-Menzel, A., 31 Oct 2023, In: Fluids and Barriers of the CNS. 20, 1, 20 p., 78.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of extracellular vesicle interactors at the blood-brain barrier by proximity-dependent biotinylation
Klepe, A. (Speaker), Spilak, A., Kriwanek, S. T., Brachner, A., Nöhammer, C. & Neuhaus, W., 4 Sept 2023, Small New Wordl 2.0 - Abstract Book. p. 42-42 1 p.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Oral Presentation
File61 Downloads (Pure) -
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment
Turner, J., Pound, P., Owen, C., Hutchinson, I., Hop, M., Chau, D. Y. S., Barrios Silva, L. V., Coleman, M., Dubourg, A., Harries, L. W., Hutter, V., Kenna, J. G., Lauschke, V. M., Neuhaus, W., Roper, C., Watkins, P. B., Welch, J., Alvarez, L. R. & Taylor, K., 20 Jul 2023, In: Altex. 40, 3, p. 519-532 14 p., 2212081.Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution
Spreitzer, I., Keife, J., Strasser, T., Kalaba, P., Lubec, J., Neuhaus, W., Lubec, G., Langer, T., Wackerlig, J. & Loryan, I., 29 Nov 2023, In: International Journal of Molecular Sciences. 24, 23, p. 16956 22 p., 16956.Research output: Contribution to journal › Article › peer-review
Open Access -
SLC7A1 is a novel candidate for the transport of therapeutics across the blood-brain barrier
Kurtyka, M. (Speaker), Wessely, F., Bau, S., M. de Wit, N., Ifie, E., He, L., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Neuhaus, W., Lesuisse, D., Buckley, S., Loryan, I. & Pietrzik, C. U., 18 Jun 2023.Research output: Poster presentation without proceedings
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Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier
Holst, M. R., de Wit, N. M., Ozgür, B., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Brodin, B., Nielsen, M. S. & Brachner, A., 6 Nov 2023, In: Fluids and Barriers of the CNS. 20, 1, p. 82Research output: Contribution to journal › Article › peer-review
Open Access -
The Cultivation Modality and Barrier Maturity Modulate the Toxicity of Industrial Zinc Oxide and Titanium Dioxide Nanoparticles on Nasal, Buccal, Bronchial, and Alveolar Mucosa Cell-Derived Barrier Models
Stuetz, H., Reihs, E. I., Neuhaus, W., Pflüger, M., Hundsberger, H., Ertl, P., Resch, C., Bauer, G., Povoden, G. & Rothbauer, M., 15 Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 21 p., 5634.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
Epping, L., Schroeter, C. B., Nelke, C., Bock, S., Gola, L., Ritter, N., Herrmann, A. M., Räuber, S., Henes, A., Fernandez-Orth, J. & Neuhaus, W., 2022, In: Cellular and Molecular Life Sciences. 79, 9, p. 479-494 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Human Stem Cell-Derived Brain-Liver Chip for Assessing Blood-Brain-Barrier Permeation of Pharmaceutical Drugs
Koenig, L., Ramme, A., Faust, D., Mayer, M., Gerhartl, A., Brachner, A., Neuhaus, W., Appelt-Menzel, A., Metzger, M., Marx, U. & Dehne, E., 2022, In: Cells. 11, 20, p. 3295-3315 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of nanoplastics on cells of the neurovascular unit
Chmielewska, A. (Speaker), Leiningen-Westerburg, M.-T., Wimmer, L., Dailey, L. A., Sudheer, M. M., Fragouli, D., Spilak, A., Brachner, A. & Neuhaus, W., 2022, EUSAAT 2022, The European Congress on 3Rs. p. 173-231 59 p.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Poster Presentation › peer-review
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Human platelet lysate as a replacement for fetal bovine serum in a human blood-brain barrier in vitro model
Brachner, A. (Speaker), Gruber, C., Bernecker, C. & Neuhaus, W., 2022.Research output: Poster presentation without proceedings › peer-review
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Human platelet lysate as a replacement for fetal bovine serum in biological barrier in vitro models
Brachner, A., Gruber, C., Burek, M., Neuhoff, A., Bernecker, C., Schlenke, P. & Neuhaus, W. (Speaker), 2022, EUSAAT 2022, The European Congress on 3Rs. p. 170-231 62 p.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Poster Presentation › peer-review
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Interaction and transport of small extracellular vesicles across human biological barrier in vitro models
Klepe, A. (Speaker), Spilak, A., Kriwanek, S. T., Brachner, A., Nöhammer, C. & Neuhaus, W., 2022, EUSAAT 2022, The European Congress on 3Rs. p. 172-231 60 p.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Poster Presentation › peer-review
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Interaction and transport of small extracellular vesicles across human blood-brain barrier in vitro models
Klepe, A. (Speaker), Spilak, A., Kriwanek, S. T., Brachner, A., Nöhammer, C. & Neuhaus, W., 2022.Research output: Poster presentation without proceedings › peer-review
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INTERACTION BETWEEN SMALL EXTRACELLULAR VESICLES AND HUMAN BLOOD-BRAIN BARRIER IN VITRO MODELS
Spilak, A. (Speaker), Kriwanek, S. T., Brachner, A., Nöhammer, C. & Neuhaus, W., 2022.Research output: Poster presentation without proceedings › peer-review
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International project Train-SafeMDs: Towards the development of an in vitro testing strategy for local tolerance testing of medical devices used in the oral cavity
Kandarova, H. (Speaker), Jirova, D., Neuhaus, W., Kejlova, K., Dvorakova, M., Svobodová, L., Mousilova, A., Rucki, M., Spilak, A. & Pôbis, P., 2022, EUSAAT 2022, The European Congress on 3Rs. p. 79-231 153 p.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Poster Presentation › peer-review
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METHOD OPTIMISATION FOR IN VITRO SMALL EXTRACELLULAR VESICLE STUDIES AT THE BLOOD-BRAIN BARRIER
Klepe, A. (Speaker), Spilak, A., Brachner, A., Nöhammer, C. & Neuhaus, W., 2022.Research output: Poster presentation without proceedings › peer-review
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Physiology, Pharmacology and Pathology of the Blood-Brain Barrier
Cader, Z. (Editor) & Neuhaus, W. (Editor), 2022, Springer. 364 p.Research output: Books and Reports › Book
Open Access -
Risk assessment of medical devices for the oral cavity using a human oral mucosa epithelium model
Spilak, A. (Speaker), Pôbis, P., Svobodová, L., Moulisová, A., Brachner, A., Dvorakova, M., Kandarova, H., Jirova, D., Kejlova, K. & Neuhaus, W., 2022, EUSAAT 2022, The European Congress on 3Rs. p. 171-231 61 p.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Poster Presentation › peer-review
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TAT-MeCP2 protein variants rescue disease phenotypes in human and mouse models of Rett syndrome.
Steinkellner, H., Kempaiah, P., Beribisky, A., Pferschy, S., Etzler, J., Huber, A., Sarne, V., Neuhaus, W., Kuttke, M., Bauer, J., Arunachalam, J. P., Christodoulou, J., Dressel, R., Mildner, A., Prinz, M. & Laccone, F., 2022, In: International Journal of Biological Macromolecules. 209, p. 972-983 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
Krasemann, S., Haferkamp, U., Pfefferle, S., Woo, M., Heinrich, F., Schweizer, M., Appelt-Menzel, A., Cubukova, A., Barenberg, J., Leu, J., Hartmann, K., Thies, E., Littau, J.-L., Sepulveda-Falla, D., Zhang, L., Ton, K., Liang, Y., Matschke, J., Ricklefs, F. & Sauvigny, T. & 20 others, , 2022, In: Stem Cell Reports. 17, 17, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Current Status and Work of Three Rs Centres and Platforms in Europe
Neuhaus, W., Reininger-Gutmann, B., Plasenzotti, R., Wilflingseder, D., Vanhaecke, T., Rogiers, V., Jirova, D., Kejlova, K., Knudsen, L. E., Kleuser, B., Kral, V., Thöne-Reineke, C., Pallocca, G., Rovida, C., Leist, M., Lang, A., Retter, I., Ameli, K., Fritsche, E. & Tigges, J. & 6 others, , 2022, In: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 50, 6, p. 381-413 33 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Rise of Three Rs Centres and Platforms in Europe*
Neuhaus, W., Reininger-Gutmann, B., Rinner, B., Plasenzotti, R., Wilflingseder, D., De Kock, J., Vanhaecke, T., Rogiers, V., Jirova, D., Kejlova, K., Knudsen, L. E., Nielsen, R. N., Kleuser, B., Kral, V., Thöne-Reineke, C., Hartung, T., Pallocca, G., Leist, M., Hippenstiel, S. & Lang, A. & 7 others, , 2022, In: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 50, 2, p. 90-120 31 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Updates of the EU3Rnet
Neuhaus, W. (Speaker), 2022, EUSAAT 2022, The European Congress on 3Rs. p. 169-231 63 p.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Oral Presentation › peer-review
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2021
A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood-Brain Barrier Transport Properties
Eilenberger, C., Rothbauer, M., Selinger, F., Gerhartl, A., Jordan, C., Harasek, M., Schädl, B., Grillari, J., Weghuber, J., Neuhaus, W., Küpcü, S. & Ertl, P., 2021, In: Advanced Science. 1, 2004856, p. 1-20 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An Alzheimer´s disease-specific iPSC-derived blood-brain barrier model to study the role of APOE4
Hartmann, C. (Speaker), Haferkamp, U., Gerhartl, A., Peter, L.-M., Pless, O., Neuhaus, W., Appelt-Menzel, A., Rujescu, D. & Jung, M., 2021, Abstract Book.Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Poster Presentation › peer-review
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Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
Schick, M., Pippir, J., Struck, M., Brugger, J., Neuhaus, W. & Wunder, C., 2021, In: BMC Research Notes. 14, 434, p. 1-6 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Consensus Statement from the European Network of 3R Centres (EU3Rnet)
Neuhaus, W., 2021, In: ALTEX Alternativen zu Tierexperimenten. 1, 38, p. 1-2 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Directed Transport of CRP Across In Vitro Models of the Blood-Saliva Barrier Strengthens the Feasibility of Salivary CRP as Biomarker for Neonatal Sepsis
Lin, G., Küng, E., Smajlhodzic, M., Domazet, S., Friedl, H.-P., Angerer, J., Wisgrill, L., Berger, A., Bingle, L., Peham, J. R. & Neuhaus, W., 2021, In: Pharmaceutics. p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Epigenetics and its implications for tissue regeneration and regenerative medicine with a focus on DNA-methylation - Meteor
Hanak, K., Neuhaus, W. & Weinhäusel, A., 2021, Der Springer-Verlag und seine Autoren. Springer, p. 1 1 p.Research output: Chapter in Book or Conference Proceedings › Book chapter
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Hydroxyethylstarch revisited for acute brain injury treatment
Schick, M., Burek, M., Förster, C., Nagai, M., Wunder, C. & Neuhaus, W., 2021, In: Neural Regeneration Research. 16, 7, p. 1372-1376 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Implications and pitfalls for cancer diagnostics exploiting extracellular vesicles.
Spilak, A., Brachner, A., Kegler, U., Neuhaus, W. & Nöhammer, C., 2021, In: Advanced Drug Delivery Reviews. 1, 175, p. 113816 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Open letter: Selection of a new Executive Director of the European Chemicals Agency (ECHA) provides an opportunity for the EU to lead in the field of chemicals management and implementation of innovative science
Seidle, T., Kandarova, H., Hartung, T., Leist, M., Neuhaus, W., Spielmann, H. & Rovida, C., 2021, In: ALTEX Alternativen zu Tierexperimenten. 1, 39, p. 1-2 2 p.Research output: Contribution to journal › Article › peer-review
Open Access