Research output per year
Research output per year
Research output
- 45 results
Search results
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2024
Effects of small extracellular vesicles derived from normoxia- and hypoxia-treated prostate cancer cells on the submandibular salivary gland epithelium in vitro
Špilak, A., Brachner, A., Friedl, H.-P., Klepe, A., Nöhammer, C. & Neuhaus, W., 9 May 2024, In: Tissue Barriers. p. 2347062Research output: Contribution to journal › Article › peer-review
Open Access -
Generation and Characterization of a Human Neuronal In Vitro Model for Rett Syndrome Using a Direct Reprogramming Method
Huber, A., Sarne, V., Beribisky, A. V., Ackerbauer, D., Derdak, S., Madritsch, S., Etzler, J., Huck, S., Scholze, P., Gorgulu, I., Christodoulou, J., Studenik, C. R., Neuhaus, W., Connor, B., Laccone, F. & Steinkellner, H., 4 Mar 2024, In: Stem Cells and Development. 33, 5-6, p. 128-142 15 p.Research output: Contribution to journal › Article › peer-review
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New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P. J., Escher, B. I., Dirven, H., Hellsten, K., Dolva, K., Hessel, E., Heusinkveld, H. J., Hadzhiev, Y., Hurem, S., Jagiello, K., Judzinska, B., Klüver, N. & Knoll-Gellida, A. & 14 others, , 26 Apr 2024, In: Frontiers in Toxicology. 6, p. 1359507Research output: Contribution to journal › Article › peer-review
Open Access -
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Bell, R. D., Letoha, T., Meyer, A. H. & Leparc, G. & 7 others, , 21 Mar 2024, In: European Journal of Cell Biology. 103, 2, p. 151406Research output: Contribution to journal › Article › peer-review
Open Access -
Transport of Non-Steroidal Anti-Inflammatory Drugs across an Oral Mucosa Epithelium In Vitro Model
Lin, G., Friedl, H.-P., Grabner, S., Gerhartl, A. & Neuhaus, W., 15 Apr 2024, In: Pharmaceutics. 543.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A hydrogel model of the human blood-brain barrier using differentiated stem cells
Singh, N. R., Gromnicova, R., Brachner, A., Kraev, I., Romero, I. A., Neuhaus, W. & Male, D., 4 Apr 2023, In: PLoS ONE. 18, 4, p. e0283954 19 p., e0283954.Research output: Contribution to journal › Article › peer-review
Open Access -
A primary cell-based in vitro model of the human small intestine reveals host olfactomedin 4 induction in response to Salmonella Typhimurium infection
Däullary, T., Imdahl, F., Dietrich, O., Hepp, L., Krammer, T., Fey, C., Neuhaus, W., Metzger, M., Vogel, J., Westermann, A. J., Saliba, A.-E. & Zdzieblo, D., 20 Mar 2023, In: Gut Microbes. 15, 1, 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Ozgür, B., Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, M., Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Brodin, B., 19 Dec 2023, In: Fluids and Barriers of the CNS. 20, 15 p., 96.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases
Khalil, A., Barras, A., Boukherroub, R., Tseng, C.-L., Devos, D., Burnouf, T., Neuhaus, W. & Szunerits, S., 13 Sept 2023, In: Nanoscale Horizons. 9, 1, p. 14-43 30 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease
Haferkamp, U., Hartmann, C., Abid, C. L., Brachner, A., Höchner, A., Gerhartl, A., Harwardt, B., Leckzik, S., Leu, J., Metzger, M., Nastainczyk-Wulf, M., Neuhaus, W., Oerter, S., Pless, O., Rujescu, D., Jung, M. & Appelt-Menzel, A., 31 Oct 2023, In: Fluids and Barriers of the CNS. 20, 1, 20 p., 78.Research output: Contribution to journal › Article › peer-review
Open Access -
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment
Turner, J., Pound, P., Owen, C., Hutchinson, I., Hop, M., Chau, D. Y. S., Barrios Silva, L. V., Coleman, M., Dubourg, A., Harries, L. W., Hutter, V., Kenna, J. G., Lauschke, V. M., Neuhaus, W., Roper, C., Watkins, P. B., Welch, J., Alvarez, L. R. & Taylor, K., 20 Jul 2023, In: Altex. 40, 3, p. 519-532 14 p., 2212081.Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution
Spreitzer, I., Keife, J., Strasser, T., Kalaba, P., Lubec, J., Neuhaus, W., Lubec, G., Langer, T., Wackerlig, J. & Loryan, I., 29 Nov 2023, In: International Journal of Molecular Sciences. 24, 23, p. 16956 22 p., 16956.Research output: Contribution to journal › Article › peer-review
Open Access -
Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier
Holst, M. R., de Wit, N. M., Ozgür, B., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Brodin, B., Nielsen, M. S. & Brachner, A., 6 Nov 2023, In: Fluids and Barriers of the CNS. 20, 1, p. 82Research output: Contribution to journal › Article › peer-review
Open Access -
The Cultivation Modality and Barrier Maturity Modulate the Toxicity of Industrial Zinc Oxide and Titanium Dioxide Nanoparticles on Nasal, Buccal, Bronchial, and Alveolar Mucosa Cell-Derived Barrier Models
Stuetz, H., Reihs, E. I., Neuhaus, W., Pflüger, M., Hundsberger, H., Ertl, P., Resch, C., Bauer, G., Povoden, G. & Rothbauer, M., 15 Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 21 p., 5634.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
Epping, L., Schroeter, C. B., Nelke, C., Bock, S., Gola, L., Ritter, N., Herrmann, A. M., Räuber, S., Henes, A., Fernandez-Orth, J. & Neuhaus, W., 2022, In: Cellular and Molecular Life Sciences. 79, 9, p. 479-494 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Human Stem Cell-Derived Brain-Liver Chip for Assessing Blood-Brain-Barrier Permeation of Pharmaceutical Drugs
Koenig, L., Ramme, A., Faust, D., Mayer, M., Gerhartl, A., Brachner, A., Neuhaus, W., Appelt-Menzel, A., Metzger, M., Marx, U. & Dehne, E., 2022, In: Cells. 11, 20, p. 3295-3315 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
TAT-MeCP2 protein variants rescue disease phenotypes in human and mouse models of Rett syndrome.
Steinkellner, H., Kempaiah, P., Beribisky, A., Pferschy, S., Etzler, J., Huber, A., Sarne, V., Neuhaus, W., Kuttke, M., Bauer, J., Arunachalam, J. P., Christodoulou, J., Dressel, R., Mildner, A., Prinz, M. & Laccone, F., 2022, In: International Journal of Biological Macromolecules. 209, p. 972-983 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
Krasemann, S., Haferkamp, U., Pfefferle, S., Woo, M., Heinrich, F., Schweizer, M., Appelt-Menzel, A., Cubukova, A., Barenberg, J., Leu, J., Hartmann, K., Thies, E., Littau, J.-L., Sepulveda-Falla, D., Zhang, L., Ton, K., Liang, Y., Matschke, J., Ricklefs, F. & Sauvigny, T. & 20 others, , 2022, In: Stem Cell Reports. 17, 17, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Current Status and Work of Three Rs Centres and Platforms in Europe
Neuhaus, W., Reininger-Gutmann, B., Plasenzotti, R., Wilflingseder, D., Vanhaecke, T., Rogiers, V., Jirova, D., Kejlova, K., Knudsen, L. E., Kleuser, B., Kral, V., Thöne-Reineke, C., Pallocca, G., Rovida, C., Leist, M., Lang, A., Retter, I., Ameli, K., Fritsche, E. & Tigges, J. & 6 others, , 2022, In: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 50, 6, p. 381-413 33 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Rise of Three Rs Centres and Platforms in Europe*
Neuhaus, W., Reininger-Gutmann, B., Rinner, B., Plasenzotti, R., Wilflingseder, D., De Kock, J., Vanhaecke, T., Rogiers, V., Jirova, D., Kejlova, K., Knudsen, L. E., Nielsen, R. N., Kleuser, B., Kral, V., Thöne-Reineke, C., Hartung, T., Pallocca, G., Leist, M., Hippenstiel, S. & Lang, A. & 7 others, , 2022, In: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 50, 2, p. 90-120 31 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood-Brain Barrier Transport Properties
Eilenberger, C., Rothbauer, M., Selinger, F., Gerhartl, A., Jordan, C., Harasek, M., Schädl, B., Grillari, J., Weghuber, J., Neuhaus, W., Küpcü, S. & Ertl, P., 2021, In: Advanced Science. 1, 2004856, p. 1-20 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Comparison of hydroxyethylstarch (HES 130/0.4) and 5% human albumin for volume substitution in pediatric neurosurgery: A retrospective, single center study
Schick, M., Pippir, J., Struck, M., Brugger, J., Neuhaus, W. & Wunder, C., 2021, In: BMC Research Notes. 14, 434, p. 1-6 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Consensus Statement from the European Network of 3R Centres (EU3Rnet)
Neuhaus, W., 2021, In: ALTEX Alternativen zu Tierexperimenten. 1, 38, p. 1-2 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Directed Transport of CRP Across In Vitro Models of the Blood-Saliva Barrier Strengthens the Feasibility of Salivary CRP as Biomarker for Neonatal Sepsis
Lin, G., Küng, E., Smajlhodzic, M., Domazet, S., Friedl, H.-P., Angerer, J., Wisgrill, L., Berger, A., Bingle, L., Peham, J. R. & Neuhaus, W., 2021, In: Pharmaceutics. p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Hydroxyethylstarch revisited for acute brain injury treatment
Schick, M., Burek, M., Förster, C., Nagai, M., Wunder, C. & Neuhaus, W., 2021, In: Neural Regeneration Research. 16, 7, p. 1372-1376 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Implications and pitfalls for cancer diagnostics exploiting extracellular vesicles.
Spilak, A., Brachner, A., Kegler, U., Neuhaus, W. & Nöhammer, C., 2021, In: Advanced Drug Delivery Reviews. 1, 175, p. 113816 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Open letter: Selection of a new Executive Director of the European Chemicals Agency (ECHA) provides an opportunity for the EU to lead in the field of chemicals management and implementation of innovative science
Seidle, T., Kandarova, H., Hartung, T., Leist, M., Neuhaus, W., Spielmann, H. & Rovida, C., 2021, In: ALTEX Alternativen zu Tierexperimenten. 1, 39, p. 1-2 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Transendothelial Electrical Resistance Measurement across the Blood-Brain Barrier: A Critical Review of Methods
Vigh, J. P., Kincses, A., Ozgür, B., Walter, F. R., Santa-Maria, R., Valkai, S., Vastag, M., Neuhaus, W., Brodin, B., Der, A. & Deli, M. A., 2021, In: Micromachines. 685, p. 1-18 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
An In Vitro Barrier Model of the Human Submandibular Salivary Gland Epithelium Based on a Single Cell Clone of Cell Line HTB-41: Establishment and Application for Biomarker Transport Studies
Lin, G., Smajlhodzic, M., Bandian, A.-M., Friedl, H.-P., Leitgeb, T., Oerter, S., Stadler, K., Giese, U., Peham, J. R., Bingle, L. & Neuhaus, W., 2020, In: Biomedicines. 8, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Assessment of Human Health Risks Posed by Nano-and Microplastics Is Currently Not Feasible
Brachner, A., Fraqouli, D., Duarte, I. F., Farias, P. M. A., Dembski, S., Ghosh, M., Barisic, I., Zdzieblo, D., Vanoirbeek, J., Schwabl, P. & Neuhaus, W., 2020, In: International Journal of Environmental Research and Public Health. p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development?
Appelt-Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W. & Pless, O., 2020, In: Curr Protoc Stem Cell Biol. 55, 55, p. 1-27 27 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Optimization of an Oral Mucosa in vitro Model Based on Cell Line TR146
Lin, G., Leitgeb, T., Vladetic, A., Friedl, H.-P., Rhodes, N., Rossi, A., Roblegg, E. & Neuhaus, W., 2020, In: Tissue Barriers. 1, 1, p. 1-23 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The pivotal role of micro-environmental cells in a human blood-brain barrier in vitro model of cerebral ischemia: functional and transcriptomic analysis
Gerhartl, A., Pracser, N., Vladetic, A., Hendrikx, S., Friedl, H.-P. & Neuhaus, W., 2020, In: Fluids and Barriers of the CNS. p. 1-17 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
An electrochemiluminescence based assay for quantitative detection of endogenous and exogenously applied MeCP2 protein variants
Steinkellner, H., Schönegger, A., Etzler, J., Kempaiah, P., Huber, A., Hahn, K., Rose, K., Duerr, M., Beribisky, A., Christodoulou, J., Neuhaus, W. & Laccone, F., 2019, In: Scientific Reports. 1, p. 1 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Autologous iPSC-derived four-organ-chip
Ramme, A., Koenig, L., Hasenberg, T., Schwenk, C., Magauer, C., Faust, D., Lorenz, A., Krebs, A., Drewell, C., Schirrmann, K., Vladetic, A., Lin, G., Pabinger, S., Neuhaus, W., Bois, F., Lauser, R., Marx, U. & Dehne, E., 2019, In: Future Science OA. 8, 5, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Hydroxyethylstarch (130/0.4) tightens the blood-brain barrier in vitro
Gerhartl, A., Hahn, K., Neuhoff, A., Friedl, H.-P., Förster, C., Wunder, C., Schick, M., Burek, M. & Neuhaus, W., 2019, In: Brain Research. 1, p. 1-7 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Oxygen management at the microscale: A functional biochip material with long-lasting and tunable oxygen scavenging properties for cell culture applications
Sticker, D., Rothbauer, M., Ehgartner, J., Steininger, C., Liske, O., Liska, R., Neuhaus, W., Mayr, T., Haraldsson, T., Kutter, J. P. & Ertl, P., 2019, In: ACS applied materials & interfaces. 2019, 1, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Plasminogen activator inhibitor-1 augments damage by impairing fibrinolysis after traumatic brain injury
Griemert, E., Schwarzmaier, S., Hummel, R., Gölz, C., Yang, D., Neuhaus, W., Burek, M., Förster, C., Petkovic, I., Trabold, R., Plesnila, N., Engelhard, K., Schäfer, M. & Thal, S. C., 2019, In: Annals of Neurology. 85, 5, p. 667-680 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval
Kristofova, M., Aher, Y. D., Ilic, M., Radoman, B., Kalaba, P., Dragacevic, V., Leban, J., Korz, V., Zanon, L., Neuhaus, W., Wieder, M., Langer, T., Urban, E., Sitte, H. H., Hoeger, H., Lubec, G. & Aradska, J., 2018, In: Behavioural Brain Research. 343, 343, p. 83-94 12 p.Research output: Contribution to journal › Article › peer-review
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Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
Bierbaumer, L., Schwarze, U. Y., Gruber, R. & Neuhaus, W., 2018, In: Tissue Barriers. 2018, p. 1-43 43 p.Research output: Contribution to journal › Article › peer-review
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Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain
Neuhaus, W., Piontek, A., Protze, J., Eichner, M., Mahringer, A., Subileau, E., Lee, I.-F. M., Schulzke, J. D., Krause, G. & Piontek, J., 2018, In: Biomaterials. 161, 161, p. 129-143 15 p.Research output: Contribution to journal › Article › peer-review
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Towards an autologous iPSC-derived patient-on-a-chip
Ramme, A., Koenig, L., Schwenk, C., Magauer, C., Faust, D., Lorenz, A., Krebs, A., Drewell, C., Schirrmann, K., Vladetic, A., Lin, G., Pabinger, S., Neuhaus, W., Bois, F., Lauster, R., Marx, U. & Dehne, E., 2018, In: bioRxiv. 1, 1, p. 1 1 p.Research output: Contribution to journal › Article
Open Access -
2017
Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells
Appelt-Menzel, A., Cubukova, A., Guenther, K., Edenhofer, F., Piontek, J., Krause, G., Stueber, T., Walles, H., Neuhaus, W. & Metzger, M., 2017, In: Stem Cell Reports. 8, p. 1-13 13 p.Research output: Contribution to journal › Article › peer-review
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Human induced pluripotent stem cell based in vitro models of the blood-brain barrier: the future standard?
Neuhaus, W., 2017, In: Neural Regeneration Research. 12, p. 1607-1609 3 p.Research output: Contribution to journal › Article › peer-review
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Multifaceted mechanisms of WY-14643 to stabilize the blood-brain barrier in a model of traumatic brain injury
Neuhaus, W., Tobias, K., Anja, N., Goelz, C., Thal, S. C. & Foerster, C. Y., 2017, In: Frontiers in Molecular Neuroscience. 10, 149, p. 1-15 15 p.Research output: Contribution to journal › Article › peer-review