Conservation and divergence in developmental networks: a view from Drosophila myogenesis

Lucia Ciglar, Eileen E M Furlong

Research output: Contribution to journalArticlepeer-review


Understanding developmental networks has recently been enhanced through the identification of a large number of conserved essential regulators. Interspecies comparisons of the transcriptional networks regulated by these factors are still at a rather early stage, with limited global data available. Here we use the accumulating phenotypic information from multiple species to provide initial insights into the wiring and rewiring of developmental networks, with particular emphasis on myogenesis, a highly conserved developmental process. This review highlights the most recent findings on the transcriptional program driving Drosophila myogenesis and compares this with vertebrates, revealing emerging themes that may be applicable to other developmental contexts.

Original languageEnglish
Pages (from-to)754-60
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number6
Publication statusPublished - Dec 2009

Research Field

  • Outside the AIT Research Fields


  • Animals
  • Body Patterning/genetics
  • Drosophila/embryology
  • Drosophila Proteins/genetics
  • Gene Expression Regulation, Developmental
  • Gene Regulatory Networks
  • Genes, Insect
  • Genome, Insect
  • Humans
  • Muscle Development/genetics


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