Developing technologies to assess vascular ageing: a roadmap from VascAgeNet

Serena Zanelli; Davide Agnoletti; Jordi Alastruey; John Allen; Elisabetta Bianchini; Vasiliki Bikia; Pierre Boutouyrie; Rosa Maria Bruno; Rachel Climie; Djammaleddine Djeldjli; Eugenia Gkaliagkousi; Alessandro Giudici; Kristina Gopcevic; Andrea Grillo; Andrea Guala; Bernhard Hametner; Jayaraj Joseph; Parmis Karimpour; Vimarsha Kodithuwakku; Panicos A Kyriacou; Antonios Lazaridis; Mai Tone Lønnebakken; Maria Raffaella Martina; Christopher Clemens Mayer; P M Nabeel; Petras Navickas; János Nemcsik; Stefan Orter; Chloe Park; Telmo Pereira; Giacomo Pucci; Ana Belen Amado Rey; Paolo Salvi; Ana Carolina Gonçalves Seabra; Ute Seeland; Thomas van Sloten; Bart Spronck; Gerard Stansby; Indra Steens; Thomas Stieglitz; Isabella Tan; Dave Veerasingham; Siegfried Wassertheurer; Thomas Weber; Berend E Westerhof; Peter H Charlton

doi:10.1088/1361-6579/ad548e

Developing technologies to assess vascular ageing: a roadmap from VascAgeNet

Serena Zanelli
, Davide Agnoletti
, Jordi Alastruey
, John Allen
, Elisabetta Bianchini
, Vasiliki Bikia
, Pierre Boutouyrie
, Rosa Maria Bruno
, Rachel Climie
, Djammaleddine Djeldjli
, Eugenia Gkaliagkousi
, Alessandro Giudici
, Kristina Gopcevic
, Andrea Grillo
, Andrea Guala
, Bernhard Hametner
, Jayaraj Joseph
, Parmis Karimpour
, Vimarsha Kodithuwakku
, Panicos A Kyriacou

Antonios Lazaridis, Mai Tone Lønnebakken, Maria Raffaella Martina, Christopher Clemens Mayer, P M Nabeel, Petras Navickas, János Nemcsik, Stefan Orter, Chloe Park, Telmo Pereira, Giacomo Pucci, Ana Belen Amado Rey, Paolo Salvi, Ana Carolina Gonçalves Seabra, Ute Seeland, Thomas van Sloten, Bart Spronck, Gerard Stansby, Indra Steens, Thomas Stieglitz, Isabella Tan, Dave Veerasingham, Siegfried Wassertheurer, Thomas Weber, Berend E Westerhof, Peter H Charlton

Université Sorbonne Paris Nord
Axelife
University of Bologna
IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant'Orsola
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London
Coventry University
Newcastle University
CNR-IFC - National Research Council Institute of Clinical Physiology
Stanford University
Swiss Federal Institute of Technology Lausanne
Paris Cardiovascular Research Center (PARCC)
University of Tasmania
Université de Lorraine
Aristotle University of Thessaloniki
Cardiovascular Research Institute Maastricht (CARIM)
Maastricht University
University of Belgrade
University of Trieste
Vall d’Hebron Institut de Recerca
CIBER-CV, Instituto de Salud Carlos III, Madrid, Spain
Indian Institute of Technology Madras
City St George's, University of London
Department of Heart Disease, Haukeland University Hospital
Department of Clinical Science, University of Bergen
Healthcare Technology Innovation Centre (HTIC)
Vilnius University
Semmelweis University
MRC Unit for lifelong Health and Ageing at UCL, London
Instituto Politécnico de Coimbra (IPC)
University of Perugia
Internal Medicine Unit, “Santa Maria” Terni Hospital, Terni
Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering—IMTEK, IMBIT—NeuroProbes, BrainLinks-BrainTools Center, University of Freiburg
IRCCS Istituto Auxologico Italiano - Milano
Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medicine Berlin
University Medical Center Utrecht
Macquarie University
Freeman Hospital
Bernstein Center Freiburg
The George Institute for Global Health
University Hospital Galway
Cardiology Department, Klinikum Wels-Grieskirchen
Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam
Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children’s Hospital
University of Cambridge

Research output: Contribution to journal › Article › peer-review

Abstract

Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. However, vascular ageing is not yet routinely assessed in clinical practice. A key step towards this is the development of technologies to assess vascular ageing. In this Roadmap, experts discuss several aspects of this process, including: measurement technologies; the development pipeline; clinical applications; and future research directions. The Roadmap summarises the state of the art, outlines the major challenges to overcome, and identifies potential future research directions to address these challenges.

Original language	English
Article number	121001
Pages (from-to)	1-89
Number of pages	89
Journal	Physiological Measurement
Volume	45
Issue number	12
DOIs	https://doi.org/10.1088/1361-6579/ad548e
Publication status	Published - 30 Dec 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Field

Medical Signal Analysis

Keywords

Humans
Aging/physiology
Blood Vessels/physiology
ageing
arterial stiffness
blood pressure
cardiovascular
commercialisation
prevention
pulse wave velocity

Access to Document

10.1088/1361-6579/ad548eLicence: CC BY

Cite this

Zanelli, S., Agnoletti, D., Alastruey, J., Allen, J., Bianchini, E., Bikia, V., Boutouyrie, P., Bruno, R. M., Climie, R., Djeldjli, D., Gkaliagkousi, E., Giudici, A., Gopcevic, K., Grillo, A., Guala, A., Hametner, B., Joseph, J., Karimpour, P., Kodithuwakku, V., ... Charlton, P. H. (2024). Developing technologies to assess vascular ageing: a roadmap from VascAgeNet. Physiological Measurement, 45(12), 1-89. Article 121001. https://doi.org/10.1088/1361-6579/ad548e

@article{f9f0b2aa894c45208ffa9235ac7d3539,

title = "Developing technologies to assess vascular ageing: a roadmap from VascAgeNet",

abstract = "Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. However, vascular ageing is not yet routinely assessed in clinical practice. A key step towards this is the development of technologies to assess vascular ageing. In this Roadmap, experts discuss several aspects of this process, including: measurement technologies; the development pipeline; clinical applications; and future research directions. The Roadmap summarises the state of the art, outlines the major challenges to overcome, and identifies potential future research directions to address these challenges.",

keywords = "Humans, Aging/physiology, Blood Vessels/physiology, ageing, arterial stiffness, blood pressure, cardiovascular, commercialisation, prevention, pulse wave velocity",

author = "Serena Zanelli and Davide Agnoletti and Jordi Alastruey and John Allen and Elisabetta Bianchini and Vasiliki Bikia and Pierre Boutouyrie and Bruno, \{Rosa Maria\} and Rachel Climie and Djammaleddine Djeldjli and Eugenia Gkaliagkousi and Alessandro Giudici and Kristina Gopcevic and Andrea Grillo and Andrea Guala and Bernhard Hametner and Jayaraj Joseph and Parmis Karimpour and Vimarsha Kodithuwakku and Kyriacou, \{Panicos A\} and Antonios Lazaridis and L{\o}nnebakken, \{Mai Tone\} and Martina, \{Maria Raffaella\} and Mayer, \{Christopher Clemens\} and Nabeel, \{P M\} and Petras Navickas and J{\'a}nos Nemcsik and Stefan Orter and Chloe Park and Telmo Pereira and Giacomo Pucci and Rey, \{Ana Belen Amado\} and Paolo Salvi and Seabra, \{Ana Carolina Gon{\c c}alves\} and Ute Seeland and \{van Sloten\}, Thomas and Bart Spronck and Gerard Stansby and Indra Steens and Thomas Stieglitz and Isabella Tan and Dave Veerasingham and Siegfried Wassertheurer and Thomas Weber and Westerhof, \{Berend E\} and Charlton, \{Peter H\}",

note = "{\textcopyright} 2024 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd",

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month = dec,

day = "30",

doi = "10.1088/1361-6579/ad548e",

language = "English",

volume = "45",

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journal = "Physiological Measurement",

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Zanelli, S, Agnoletti, D, Alastruey, J, Allen, J, Bianchini, E, Bikia, V, Boutouyrie, P, Bruno, RM, Climie, R, Djeldjli, D, Gkaliagkousi, E, Giudici, A, Gopcevic, K, Grillo, A, Guala, A, Hametner, B, Joseph, J, Karimpour, P, Kodithuwakku, V, Kyriacou, PA, Lazaridis, A, Lønnebakken, MT, Martina, MR, Mayer, CC, Nabeel, PM, Navickas, P, Nemcsik, J, Orter, S, Park, C, Pereira, T, Pucci, G, Rey, ABA, Salvi, P, Seabra, ACG, Seeland, U, van Sloten, T, Spronck, B, Stansby, G, Steens, I, Stieglitz, T, Tan, I, Veerasingham, D, Wassertheurer, S, Weber, T, Westerhof, BE & Charlton, PH 2024, 'Developing technologies to assess vascular ageing: a roadmap from VascAgeNet', Physiological Measurement, vol. 45, no. 12, 121001, pp. 1-89. https://doi.org/10.1088/1361-6579/ad548e

TY - JOUR

T1 - Developing technologies to assess vascular ageing

T2 - a roadmap from VascAgeNet

AU - Zanelli, Serena

AU - Agnoletti, Davide

AU - Alastruey, Jordi

AU - Allen, John

AU - Bianchini, Elisabetta

AU - Bikia, Vasiliki

AU - Boutouyrie, Pierre

AU - Bruno, Rosa Maria

AU - Climie, Rachel

AU - Djeldjli, Djammaleddine

AU - Gkaliagkousi, Eugenia

AU - Giudici, Alessandro

AU - Gopcevic, Kristina

AU - Grillo, Andrea

AU - Guala, Andrea

AU - Hametner, Bernhard

AU - Joseph, Jayaraj

AU - Karimpour, Parmis

AU - Kodithuwakku, Vimarsha

AU - Kyriacou, Panicos A

AU - Lazaridis, Antonios

AU - Lønnebakken, Mai Tone

AU - Martina, Maria Raffaella

AU - Mayer, Christopher Clemens

AU - Nabeel, P M

AU - Navickas, Petras

AU - Nemcsik, János

AU - Orter, Stefan

AU - Park, Chloe

AU - Pereira, Telmo

AU - Pucci, Giacomo

AU - Rey, Ana Belen Amado

AU - Salvi, Paolo

AU - Seabra, Ana Carolina Gonçalves

AU - Seeland, Ute

AU - van Sloten, Thomas

AU - Spronck, Bart

AU - Stansby, Gerard

AU - Steens, Indra

AU - Stieglitz, Thomas

AU - Tan, Isabella

AU - Veerasingham, Dave

AU - Wassertheurer, Siegfried

AU - Weber, Thomas

AU - Westerhof, Berend E

AU - Charlton, Peter H

PY - 2024/12/30

Y1 - 2024/12/30

N2 - Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. However, vascular ageing is not yet routinely assessed in clinical practice. A key step towards this is the development of technologies to assess vascular ageing. In this Roadmap, experts discuss several aspects of this process, including: measurement technologies; the development pipeline; clinical applications; and future research directions. The Roadmap summarises the state of the art, outlines the major challenges to overcome, and identifies potential future research directions to address these challenges.

AB - Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. However, vascular ageing is not yet routinely assessed in clinical practice. A key step towards this is the development of technologies to assess vascular ageing. In this Roadmap, experts discuss several aspects of this process, including: measurement technologies; the development pipeline; clinical applications; and future research directions. The Roadmap summarises the state of the art, outlines the major challenges to overcome, and identifies potential future research directions to address these challenges.

KW - Humans

KW - Aging/physiology

KW - Blood Vessels/physiology

KW - ageing

KW - arterial stiffness

KW - blood pressure

KW - cardiovascular

KW - commercialisation

KW - prevention

KW - pulse wave velocity

U2 - 10.1088/1361-6579/ad548e

DO - 10.1088/1361-6579/ad548e

M3 - Article

C2 - 38838703

SN - 0967-3334

VL - 45

SP - 1

EP - 89

JO - Physiological Measurement

JF - Physiological Measurement

IS - 12

M1 - 121001

ER -

Developing technologies to assess vascular ageing: a roadmap from VascAgeNet

Abstract

UN SDGs

Research Field

Keywords

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