Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients

Gaye Hafez, Jolanta Malyszko, Aleksandra Golenia, Aleksandra Klimkowicz-Mrowiec, Mustafa Arıcı, Annette Bruchfeld, Dorothea Nitsch, Ziad A Massy, Marion Pépin, Giovambattista Capasso, Laila-Yasmin Mani, Sophie Liabeuf,

Research output: Contribution to journalArticlepeer-review

Abstract

There is growing evidence that chronic kidney disease (CKD) is an independent risk factor for cognitive impairment, especially due to vascular damage, blood-brain barrier disruption and uremic toxins. Given the presence of multiple comorbidities, the medication regimen of CKD patients often becomes very complex. Several medications such as psychotropic agents, drugs with anticholinergic properties, GABAergic drugs, opioids, corticosteroids, antibiotics and others have been linked to negative effects on cognition. These drugs are frequently included in the treatment regimen of CKD patients. The first review of this series described how CKD could represent a risk factor for adverse drug reactions affecting the central nervous system. This second review will describe some of the most common medications associated with cognitive impairment (in the general population and in CKD) and describe their effects.
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Original languageEnglish
Pages (from-to)2378-2392
Number of pages15
JournalCKJ: Clinical Kidney Journal
Volume16
Issue number12
DOIs
Publication statusPublished - 18 Sept 2023

Research Field

  • Medical Signal Analysis

Keywords

  • Adverse drug reaction
  • Chronic kidney disease
  • Cognitive impairment
  • Drug prescription
  • Medications

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