Abstract
This paper describes a gas chromatography (GC)-mass spectrometry (MS) method for the simultaneous quantification of ephedrine, pseudoephedrine, cathine, norephedrine and methylephedrine in urine. The sample preparation step includes solid phase extraction and derivatistion with N-methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA). An evaluation of various silylation conditions compatible with screening methods in doping control analysis is presented. The method was found to be well suited for quantification of ephedrines in doping control.
| Original language | English |
|---|---|
| Pages (from-to) | 201-208 |
| Number of pages | 8 |
| Journal | Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences |
| Publication status | Published - 2004 |
Research Field
- Biosensor Technologies
Keywords
- Ephedrine
- Pseudoephedrine
- Cathine
- Norephedrine
- Methylephedrine
- Derivatisation
- Doping
- Silylation
- N-Methyl-N-timethylsilyltrifluoroacetamide