Microfluidic Platforms for Advanced Risk Assessments of Nanomaterial Cytotoxicity

Kumar Mahto Sanjeev, Verena Charwat, Peter Ertl, Barbara Rothen-Rutishauser, Seong Woo Rhee, Josué Sznitman

    Research output: Contribution to journalArticlepeer-review


    In the past few years, promising efforts to utilize microfabrication-based technologies have laid the foundation for developing advanced, and importantly more physiologically-realistic, microfluidic methods for risk assessment of engineered nanomaterials (ENMs). In the present review, we discuss the wave of recent developments using microfluidic-based in vitro models and platforms for nanotoxicological assays, such as determination of cell viability, cellular dose, oxidative stress and nuclear damage. Here, we specifically highlight the tangible advantages of microfluidic devices in providing promising tools to tackle many of the current and ongoing challenges faced with traditional toxicology assays. Most importantly, microfluidic technology not only allows to recreate physiologically-relevant in vitro models for nanotoxicity examinations, but also provides platforms that deliver an attractive strategy towards improved control over applied ENM doses. In a final step, we present examples of state-of-the-art microfluidic platforms for in vitro assessment of potential adverse ENM effects
    Original languageEnglish
    Pages (from-to)1-15
    Number of pages15
    Issue number2
    Publication statusPublished - 2014

    Research Field

    • Biosensor Technologies


    • cytotoxicity; engineered nanomaterials;exposure method; microfluidics; risk assessment


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