Abstract
The absorption of sup1sup4C-labelled 2.4-diaminoanisole together with its reaction products was investigated after application to the skin of rats. 2.4-diamino(sup1sup4C)anisole was applied as an ingredient of three different hair-dyeing formulations using procedures approximating to realistic conditions of use. Percutaneous absorption of the compound ranged from 0.26 to 1.1 % of the administered dose, according to the formulation used. Elimination occured mainly in the urine, with a smaller proportion in the faeces. Very small amounts were detected in the expired air. Complementary investigations involving subcutaneous or oral application of a solution of 2.4-diamino(sup1sup4C)anisole. 2HCl showed that radioactivity was rapidly eliminated in the urine and faeces. Biliary excretion was demonstrated after oral administration. (Author)
| Original language | English |
|---|---|
| Pages (from-to) | 331-334 |
| Number of pages | 4 |
| Journal | Fd Chem. Toxic.(1983) |
| Publication status | Published - 1983 |
Research Field
- Not defined
Keywords
- FZS-000BLP