Synthesis and evaluation of [18F]FBTA, a potential amyloid imaging agent

U. Berndt; C. Stanetty; M. Berger; Herbert Kvaternik; Tanja Wolf; Claudia Kuntner; Thomas Wanek; Peter Angelberger; C. Noe

Synthesis and evaluation of [18F]FBTA, a potential amyloid imaging agent

U. Berndt (Speaker), C. Stanetty, M. Berger, Herbert Kvaternik, Tanja Wolf, Claudia Kuntner, Thomas Wanek, Peter Angelberger, C. Noe

University of Vienna

Research output: Chapter in Book or Conference Proceedings › Conference Proceedings with Oral Presentation › peer-review

Abstract

ß-Amyloid(Aß)plaques and neurofibrillary tangles detected in post mortem brain are the defining characteristics of Alzheimer's disease (AD). In vitro imaging of Aß plaques could be very useful for early diagnosis and therapy monitoring of AD. A 11C-labelled benzothiazole-aniline, [11C]BTA, is the first Aß PET-tracer used in AD patients witz promising results (1).Here we report the radiosynthesis and evaluation of [18F]FBTA, a new [18F]analog of [11C]BTA.

Original language	English
Title of host publication	Journal of Labelled Compounds and Radiopharmaceuticals
Pages	86
Number of pages	1
Publication status	Published - 2007
Event	The 17th International Symposium on Radiopharmaceutical Sciences - Duration: 1 Jan 2007 → …

Conference

Conference	The 17th International Symposium on Radiopharmaceutical Sciences
Period	1/01/07 → …

Research Field

Biosensor Technologies

Keywords

[18F]FBTA
PET
Alzheimer's Disease
ß-Amyloid
[11C]BTA

Cite this

@inproceedings{91285c291d2b4e39962b35068401f49e,

title = "Synthesis and evaluation of [18F]FBTA, a potential amyloid imaging agent",

abstract = "{\ss}-Amyloid(A{\ss})plaques and neurofibrillary tangles detected in post mortem brain are the defining characteristics of Alzheimer's disease (AD). In vitro imaging of A{\ss} plaques could be very useful for early diagnosis and therapy monitoring of AD. A 11C-labelled benzothiazole-aniline, [11C]BTA, is the first A{\ss} PET-tracer used in AD patients witz promising results (1).Here we report the radiosynthesis and evaluation of [18F]FBTA, a new [18F]analog of [11C]BTA.",

keywords = "[18F]FBTA, PET, Alzheimer's Disease, {\ss}-Amyloid, [11C]BTA, [18F]FBTA, PET, Alzheimer's Disease, {\ss}-Amyloid, [11C]BTA",

author = "U. Berndt and C. Stanetty and M. Berger and Herbert Kvaternik and Tanja Wolf and Claudia Kuntner and Thomas Wanek and Peter Angelberger and C. Noe",

year = "2007",

language = "English",

pages = "86",

booktitle = "Journal of Labelled Compounds and Radiopharmaceuticals",

note = "The 17th International Symposium on Radiopharmaceutical Sciences ; Conference date: 01-01-2007",

}

TY - GEN

T1 - Synthesis and evaluation of [18F]FBTA, a potential amyloid imaging agent

AU - Stanetty, C.

AU - Berger, M.

AU - Kvaternik, Herbert

AU - Wolf, Tanja

AU - Kuntner, Claudia

AU - Wanek, Thomas

AU - Angelberger, Peter

AU - Noe, C.

A2 - Berndt, U.

PY - 2007

Y1 - 2007

N2 - ß-Amyloid(Aß)plaques and neurofibrillary tangles detected in post mortem brain are the defining characteristics of Alzheimer's disease (AD). In vitro imaging of Aß plaques could be very useful for early diagnosis and therapy monitoring of AD. A 11C-labelled benzothiazole-aniline, [11C]BTA, is the first Aß PET-tracer used in AD patients witz promising results (1).Here we report the radiosynthesis and evaluation of [18F]FBTA, a new [18F]analog of [11C]BTA.

AB - ß-Amyloid(Aß)plaques and neurofibrillary tangles detected in post mortem brain are the defining characteristics of Alzheimer's disease (AD). In vitro imaging of Aß plaques could be very useful for early diagnosis and therapy monitoring of AD. A 11C-labelled benzothiazole-aniline, [11C]BTA, is the first Aß PET-tracer used in AD patients witz promising results (1).Here we report the radiosynthesis and evaluation of [18F]FBTA, a new [18F]analog of [11C]BTA.

KW - [18F]FBTA

KW - PET

KW - Alzheimer's Disease

KW - ß-Amyloid

KW - [11C]BTA

KW - [18F]FBTA

KW - PET

KW - Alzheimer's Disease

KW - ß-Amyloid

KW - [11C]BTA

M3 - Conference Proceedings with Oral Presentation

SP - 86

BT - Journal of Labelled Compounds and Radiopharmaceuticals

T2 - The 17th International Symposium on Radiopharmaceutical Sciences

Y2 - 1 January 2007

ER -

Synthesis and evaluation of [18F]FBTA, a potential amyloid imaging agent

Abstract

Conference

Research Field

Keywords

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