TY - JOUR
T1 - Vascular ageing
T2 - moving from bench towards bedside
AU - Climie, Rachel E
AU - Alastruey, Jordi
AU - Mayer, Christopher C
AU - Schwarz, Achim
AU - Laucyte-Cibulskiene, Agne
AU - Voicehovska, Julija
AU - Bianchini, Elisabetta
AU - Bruno, Rosa-Maria
AU - Charlton, Peter H
AU - Grillo, Andrea
AU - Guala, Andrea
AU - Hallab, Magid
AU - Hametner, Bernhard
AU - Jankowski, Piotr
AU - Königstein, Karsten
AU - Lebedeva, Anna
AU - Mozos, Ioana
AU - Pucci, Giacomo
AU - Puzantian, Houry
AU - Terentes-Printzios, Dimitrios
AU - Yetik-Anacak, Gunay
AU - Park, Chloe
AU - Nilsson, Peter M
AU - Weber, Thomas
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2023/8
Y1 - 2023/8
N2 - Prevention of cardiovascular disease (CVD) remains one of the largest public health challenges of our time. Identifying individuals at increased cardiovascular risk at an asymptomatic, sub-clinical stage is of paramount importance for minimizing disease progression as well as the substantial health and economic burden associated with overt CVD. Vascular ageing (VA) involves the deterioration in vascular structure and function over time and ultimately leads to damage in the heart, brain, kidney, and other organs. Vascular ageing encompasses the cumulative effect of all cardiovascular risk factors on the arterial wall over the life course and thus may help identify those at elevated cardiovascular risk, early in disease development. Although the concept of VA is gaining interest clinically, it is seldom measured in routine clinical practice due to lack of consensus on how to characterize VA as physiological vs. pathological and various practical issues. In this state-of-the-art review and as a network of scientists, clinicians, engineers, and industry partners with expertise in VA, we address six questions related to VA in an attempt to increase knowledge among the broader medical community and move the routine measurement of VA a little closer from bench towards bedside.
AB - Prevention of cardiovascular disease (CVD) remains one of the largest public health challenges of our time. Identifying individuals at increased cardiovascular risk at an asymptomatic, sub-clinical stage is of paramount importance for minimizing disease progression as well as the substantial health and economic burden associated with overt CVD. Vascular ageing (VA) involves the deterioration in vascular structure and function over time and ultimately leads to damage in the heart, brain, kidney, and other organs. Vascular ageing encompasses the cumulative effect of all cardiovascular risk factors on the arterial wall over the life course and thus may help identify those at elevated cardiovascular risk, early in disease development. Although the concept of VA is gaining interest clinically, it is seldom measured in routine clinical practice due to lack of consensus on how to characterize VA as physiological vs. pathological and various practical issues. In this state-of-the-art review and as a network of scientists, clinicians, engineers, and industry partners with expertise in VA, we address six questions related to VA in an attempt to increase knowledge among the broader medical community and move the routine measurement of VA a little closer from bench towards bedside.
KW - Humans
KW - Cardiovascular Diseases/diagnosis
KW - Arteries
KW - Aging
UR - https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/eurjpc/30/11/10.1093_eurjpc_zwad028/1/zwad028_supplementary_data.docx?Expires=1706005061&Signature=lz~j1Xq-9GbcyVh6uiOm5aKqaDz1EF7Fcl8Zxep9bnqrRegpOYLr2pNJhsPw4JYFzmIrFOGy6wBRRnBGAJ771U6sN~jMosuafCgQ1T5eFogCD1fSNaP0uEp~3M4eoRLtHv9bJfLRqRQrZMzbd6SA0C7NlrjNF2nlKA~O00itxAVJWX5~-BCzxLG2UHyKMF3sezzgEFGIXHO-BXbZmh17aIqHK8w7dOMDs6YFtv6bkh5wSpkJEc4cgbDfjBSugLC3SqBGrH3AIUQx-wCTz5okOt17nyGG4PSo7D303XwwYrV8BP4aI7PKa~0VtZadChOth2PZKTDchoMDGqutANIFSQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
U2 - 10.1093/eurjpc/zwad028
DO - 10.1093/eurjpc/zwad028
M3 - Article
C2 - 36738307
SN - 2047-4873
VL - 30
SP - 1101
EP - 1117
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 11
ER -